• Headquartered near St. Louis, Missouri, the Monsanto Chemical Company was founded in 1901. Monsanto became a leading manufacturer of sulfuric acid and other industrial chemicals in the 1920s. In the 1930s, Monsanto began producing polychlorinated biphenyls (PCBs). PCBs, widely used as lubricants, hydraulic fluids, cutting oils, waterproof coatings and liquid sealants, are potent carcinogens and have been implicated in reproductive, developmental and immune system disorders. • The world's center of PCB manufacturing was Monsanto's plant on the outskirts of East St. Louis, Illinois, which has the highest rate of fetal death and immature births in the state. By 1982, nearby Times Beach, Missouri, was found to be so thoroughly contaminated with dioxin, a by-product of PCB manufacturing, that the government ordered it evacuated. Dioxins are endocrine and immune system disruptors, cause congenital birth defects, reproductive and developmental problems, and increase the incidence of cancer, heart disease and diabetes in laboratory animals. • By the 1940s, Monsanto had begun focusing on plastics and synthetic fabrics like polystyrene (still widely used in food packaging and other consumer products), which is ranked fifth in the EPA's 1980s listing of chemicals whose production generates the most total hazardous waste. • During World War II, Monsanto played a significant role in the Manhattan Project to develop the atom bomb. • Following the war, Monsanto championed the use of ...